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Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast

Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucida...

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Main Authors: Lee, Y.Y., Bee, P.C., Lee, C.K., Naiker, M., Ismail, R.
Format: Article
Published: 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/2773/
http://www.ncbi.nlm.nih.gov/pubmed/22346286
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spelling my.um.eprints.27732019-01-30T08:58:29Z http://eprints.um.edu.my/2773/ Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast Lee, Y.Y. Bee, P.C. Lee, C.K. Naiker, M. Ismail, R. R Medicine Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucidated sub-epidermal bulla using direct immunofluorescence, revealing linear C3 and IgG deposits along the basement membrane. His BP was recalcitrant to the conventional treatment and only responded to a combination of high dose oral prednisolone and azathioprine. The relative refractory nature of his condition and concurrent RAEB supports a paraneoplastic nature. 2011-12 Article PeerReviewed Lee, Y.Y. and Bee, P.C. and Lee, C.K. and Naiker, M. and Ismail, R. (2011) Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast. Annals of Dermatology. ISSN 1013-9087 http://www.ncbi.nlm.nih.gov/pubmed/22346286 22346286
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Lee, Y.Y.
Bee, P.C.
Lee, C.K.
Naiker, M.
Ismail, R.
Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
description Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucidated sub-epidermal bulla using direct immunofluorescence, revealing linear C3 and IgG deposits along the basement membrane. His BP was recalcitrant to the conventional treatment and only responded to a combination of high dose oral prednisolone and azathioprine. The relative refractory nature of his condition and concurrent RAEB supports a paraneoplastic nature.
format Article
author Lee, Y.Y.
Bee, P.C.
Lee, C.K.
Naiker, M.
Ismail, R.
author_facet Lee, Y.Y.
Bee, P.C.
Lee, C.K.
Naiker, M.
Ismail, R.
author_sort Lee, Y.Y.
title Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
title_short Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
title_full Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
title_fullStr Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
title_full_unstemmed Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
title_sort bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast
publishDate 2011
url http://eprints.um.edu.my/2773/
http://www.ncbi.nlm.nih.gov/pubmed/22346286
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