An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials

The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of...

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Main Authors: Razali, Masfueh, Ngeow, Wei Cheong, Omar, Ros Anita, Chai, Wen Lin
Format: Article
Published: MDPI 2021
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Online Access:http://eprints.um.edu.my/26791/
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spelling my.um.eprints.267912022-04-18T03:02:24Z http://eprints.um.edu.my/26791/ An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials Razali, Masfueh Ngeow, Wei Cheong Omar, Ros Anita Chai, Wen Lin QD Chemistry QH301 Biology RM Therapeutics. Pharmacology RS Pharmacy and materia medica The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Therefore, this study aimed to evaluate the soft tissue seal around peri-implant mucosa and to understand the effect of photofunctionalization on the abutment materials. Three types of abutment materials were used in this study; yttria-stabilized zirconia (YSZ), alumina-toughened zirconia, and grade 2 commercially pure titanium (CPTi) which were divided into nontreated (N-Tx) and photofunctionalized group (UV-Tx). The three-dimensional peri-implant mucosal model was constructed using primary human gingival keratinocytes and fibroblasts co-cultured on the acellular dermal membrane. The biological seal was determined through the concentration of tritiated water permeating the material-soft tissue interface. The biological seal formed by the soft tissue in the N-Tx group was significantly reduced compared to the UV-treated group (p < 0.001), with YSZ exhibiting the lowest permeability among all materials. Photofunctionalization of implant abutment materials improved the biological seal of the surrounding soft tissue peri-implant interface. MDPI 2021-01 Article PeerReviewed Razali, Masfueh and Ngeow, Wei Cheong and Omar, Ros Anita and Chai, Wen Lin (2021) An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials. Biomedicines, 9 (1). ISSN 2227-9059, DOI https://doi.org/10.3390/biomedicines9010078 <https://doi.org/10.3390/biomedicines9010078>. 10.3390/biomedicines9010078
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
QH301 Biology
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle QD Chemistry
QH301 Biology
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Razali, Masfueh
Ngeow, Wei Cheong
Omar, Ros Anita
Chai, Wen Lin
An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
description The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Therefore, this study aimed to evaluate the soft tissue seal around peri-implant mucosa and to understand the effect of photofunctionalization on the abutment materials. Three types of abutment materials were used in this study; yttria-stabilized zirconia (YSZ), alumina-toughened zirconia, and grade 2 commercially pure titanium (CPTi) which were divided into nontreated (N-Tx) and photofunctionalized group (UV-Tx). The three-dimensional peri-implant mucosal model was constructed using primary human gingival keratinocytes and fibroblasts co-cultured on the acellular dermal membrane. The biological seal was determined through the concentration of tritiated water permeating the material-soft tissue interface. The biological seal formed by the soft tissue in the N-Tx group was significantly reduced compared to the UV-treated group (p < 0.001), with YSZ exhibiting the lowest permeability among all materials. Photofunctionalization of implant abutment materials improved the biological seal of the surrounding soft tissue peri-implant interface.
format Article
author Razali, Masfueh
Ngeow, Wei Cheong
Omar, Ros Anita
Chai, Wen Lin
author_facet Razali, Masfueh
Ngeow, Wei Cheong
Omar, Ros Anita
Chai, Wen Lin
author_sort Razali, Masfueh
title An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
title_short An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
title_full An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
title_fullStr An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
title_full_unstemmed An in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
title_sort in-vitro analysis of peri-implant mucosal seal following photofunctionalization of zirconia abutment materials
publisher MDPI
publishDate 2021
url http://eprints.um.edu.my/26791/
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score 13.209306