A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection
Background: Penicillin is the conventional treatment for all stages of syphilis, including ocular and neurosyphilis, according to the recommendations by the Centre for Disease Control and Prevention Sexually Transmitted Disease. This case series highlighted three cases of ocular syphilis which showe...
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my.um.eprints.267752022-04-15T04:53:27Z http://eprints.um.edu.my/26775/ A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection Lim, Yi Wen Lott, Pooi Wah Mohamad, Nor Fadhilah Mohamed Iqbal, Tajunisah Begam QR180 Immunology RA0421 Public health. Hygiene. Preventive Medicine Background: Penicillin is the conventional treatment for all stages of syphilis, including ocular and neurosyphilis, according to the recommendations by the Centre for Disease Control and Prevention Sexually Transmitted Disease. This case series highlighted three cases of ocular syphilis which showed prompt treatment response as early as 24 h after the adjunctive intravitreal ceftazidime injection. Methods: Case Series. Results: In case 1, there was significant improvement in the vision and vitritis after 24 h of a single intravitreal ceftazidime injection. In case 2, the patient achieved his best vision after a total of three intravitreal injections in his left eye and one in his right eye. In case 3, there was a further resolution of perivascular sheathing and retinal haemorrhages seen 1 week after a single intravitreal ceftazidime injection. Conclusion: The efficacy of intravitreal ceftazidime injection as a local adjunctive therapy in ocular syphilis treatment is noteworthy. It can be considered in cases which show suboptimal or slower treatment response despite early commencement of systemic penicillin to prevent devastating ocular sequelae. SAGE Publications 2021-09 Article PeerReviewed Lim, Yi Wen and Lott, Pooi Wah and Mohamad, Nor Fadhilah and Mohamed Iqbal, Tajunisah Begam (2021) A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection. International Journal of STD and AIDS, 32 (10). pp. 968-973. ISSN 0956-4624, DOI https://doi.org/10.1177/09564624211011917 <https://doi.org/10.1177/09564624211011917>. 10.1177/09564624211011917 |
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QR180 Immunology RA0421 Public health. Hygiene. Preventive Medicine Lim, Yi Wen Lott, Pooi Wah Mohamad, Nor Fadhilah Mohamed Iqbal, Tajunisah Begam A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
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Background: Penicillin is the conventional treatment for all stages of syphilis, including ocular and neurosyphilis, according to the recommendations by the Centre for Disease Control and Prevention Sexually Transmitted Disease. This case series highlighted three cases of ocular syphilis which showed prompt treatment response as early as 24 h after the adjunctive intravitreal ceftazidime injection. Methods: Case Series. Results: In case 1, there was significant improvement in the vision and vitritis after 24 h of a single intravitreal ceftazidime injection. In case 2, the patient achieved his best vision after a total of three intravitreal injections in his left eye and one in his right eye. In case 3, there was a further resolution of perivascular sheathing and retinal haemorrhages seen 1 week after a single intravitreal ceftazidime injection. Conclusion: The efficacy of intravitreal ceftazidime injection as a local adjunctive therapy in ocular syphilis treatment is noteworthy. It can be considered in cases which show suboptimal or slower treatment response despite early commencement of systemic penicillin to prevent devastating ocular sequelae. |
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Article |
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Lim, Yi Wen Lott, Pooi Wah Mohamad, Nor Fadhilah Mohamed Iqbal, Tajunisah Begam |
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Lim, Yi Wen Lott, Pooi Wah Mohamad, Nor Fadhilah Mohamed Iqbal, Tajunisah Begam |
author_sort |
Lim, Yi Wen |
title |
A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
title_short |
A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
title_full |
A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
title_fullStr |
A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
title_full_unstemmed |
A case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
title_sort |
case series with literature review on adjunctive usage of intravitreal ceftazidime in ocular syphilis with human immunodeficiency virus infection |
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SAGE Publications |
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2021 |
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http://eprints.um.edu.my/26775/ |
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