Direct priming of CD8 + T cells persists in the face of Cowpox Virus Inhibitors of antigen presentation

• Main Authors: Lin, Leon C. W., Croft, Sarah N., Croft, Nathan P., Wong, Yik Chun, Smith, Stewart A., Tang, Swee-Seong, Purcell, Anthony W., Tscharke, David C., Shisler, Joanna L.
• Format: Article
• Published: 2021
• Subjects: Q Science (General); QR355 Virology
• Online Access: http://eprints.um.edu.my/26298/; https://doi.org/10.1128/JVI.00186-21

Vaccinia virus (VACV) was the vaccine used to eradicate smallpox and is being repurposed as a vaccine vector. CD8(+) T cells are key antiviral mediators but require priming to become effector or memory cells. Priming requires an interaction with dendritic cells that are either infected (direct primi...