Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models?
Parkinson's disease (PD) is the second most common neurodegenerative disease. The etiology of PD remains an enigma with no available disease modifying treatment or cure. Pharmacological compensation is the only quality of life improving treatments available. Endogenous dopaminergic neuroregener...
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my.um.eprints.261752022-02-16T07:50:12Z http://eprints.um.edu.my/26175/ Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? Vijayanathan, Yuganthini Lim, Siong Meng Tan, Maw Pin Lim, Fei Ting Majeed, Abu Bakar Abdul Ramasamy, Kalavathy R Medicine (General) Medical technology Parkinson's disease (PD) is the second most common neurodegenerative disease. The etiology of PD remains an enigma with no available disease modifying treatment or cure. Pharmacological compensation is the only quality of life improving treatments available. Endogenous dopaminergic neuroregeneration has recently been considered a plausible therapeutic strategy for PD. However, researchers have to first decipher the complexity of adult endogenous neuroregeneration. This raises the need of animal models to understand the underlying molecular basis. Mammalian models with highly conserved genetic homology might aid researchers to identify specific molecular mechanisms. However, the scarcity of adult neuroregeneration potential in mammals obfuscates such investigations. Nowadays, non-mammalian models are gaining popularity due to their explicit ability to neuroregenerate naturally without the need of external enhancements, yet these non-mammals have a much diverse gene homology that critical molecular signals might not be conserved across species. The present review highlights the advantages and disadvantages of both mammalian and non-mammalian animal models that can be essentially used to study the potential of endogenous DpN regeneration against PD. 2021 Article PeerReviewed Vijayanathan, Yuganthini and Lim, Siong Meng and Tan, Maw Pin and Lim, Fei Ting and Majeed, Abu Bakar Abdul and Ramasamy, Kalavathy (2021) Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? Neurotoxicity Research, 39 (2). pp. 504-532. ISSN 1029-8428, DOI https://doi.org/10.1007/s12640-020-00298-7 <https://doi.org/10.1007/s12640-020-00298-7>. https://doi.org/10.1007/s12640-020-00298-7 doi:10.1007/s12640-020-00298-7 |
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R Medicine (General) Medical technology Vijayanathan, Yuganthini Lim, Siong Meng Tan, Maw Pin Lim, Fei Ting Majeed, Abu Bakar Abdul Ramasamy, Kalavathy Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? |
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Parkinson's disease (PD) is the second most common neurodegenerative disease. The etiology of PD remains an enigma with no available disease modifying treatment or cure. Pharmacological compensation is the only quality of life improving treatments available. Endogenous dopaminergic neuroregeneration has recently been considered a plausible therapeutic strategy for PD. However, researchers have to first decipher the complexity of adult endogenous neuroregeneration. This raises the need of animal models to understand the underlying molecular basis. Mammalian models with highly conserved genetic homology might aid researchers to identify specific molecular mechanisms. However, the scarcity of adult neuroregeneration potential in mammals obfuscates such investigations. Nowadays, non-mammalian models are gaining popularity due to their explicit ability to neuroregenerate naturally without the need of external enhancements, yet these non-mammals have a much diverse gene homology that critical molecular signals might not be conserved across species. The present review highlights the advantages and disadvantages of both mammalian and non-mammalian animal models that can be essentially used to study the potential of endogenous DpN regeneration against PD. |
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Article |
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Vijayanathan, Yuganthini Lim, Siong Meng Tan, Maw Pin Lim, Fei Ting Majeed, Abu Bakar Abdul Ramasamy, Kalavathy |
author_facet |
Vijayanathan, Yuganthini Lim, Siong Meng Tan, Maw Pin Lim, Fei Ting Majeed, Abu Bakar Abdul Ramasamy, Kalavathy |
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Vijayanathan, Yuganthini |
title |
Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? |
title_short |
Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? |
title_full |
Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? |
title_fullStr |
Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? |
title_full_unstemmed |
Adult endogenous dopaminergic neuroregeneration against parkinson’s disease: Ideal animal models? |
title_sort |
adult endogenous dopaminergic neuroregeneration against parkinson’s disease: ideal animal models? |
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2021 |
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http://eprints.um.edu.my/26175/ https://doi.org/10.1007/s12640-020-00298-7 |
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