Structure−Activity Relationship of Polyisoprenyl Benzophenones fromGarcinia pyriferaon the Tubulin/Microtubule System

• Main Authors: Roux, Delphine, A. Hadi, A. Hamid, Thoret, Sylviane, Guénard, Daniel, Thoison, Odile, Païs, Mary, Sévenet, Thierry
• Format: Article
• Published: American Chemical Society 2000
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/26018/; https://doi.org/10.1021/np0000872

Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure - activity relationship study, including nat...