Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications

• Main Authors: Pouran, Shima Rahim, Bayrami, Abolfazl, Arvanag, Farid Mohammadi, Habibi-Yangjeh, Aziz, Soltani, Reza Darvishi Cheshmeh, Ramesh, Singh, Abdul Raman, Abdul Aziz, Chae, Keun Hwa, Khataee, Alireza, Kang, Hee Kyoung
• Format: Article
• Published: Elsevier 2020
• Subjects: TJ Mechanical engineering and machinery; TP Chemical technology
• Online Access: http://eprints.um.edu.my/25360/; https://doi.org/10.1016/j.colsurfb.2020.110878

In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p < 0.05), which is owing to the enhanced interface structure and participatory functions of the united compartments of MTSE/ZnO/Ag. © 2020