Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study
AIM: To evaluate the microstructural abnormalities of the white matter tracts (WMT) using diffusion tensor imaging (DTI) in children with global developmental delay (GDD). MATERIALS AND METHODS: Sixteen children with GDD underwent magnetic resonance imaging (MRI) and cross-sectional DTI. Formal deve...
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my.um.eprints.253372020-08-13T08:13:29Z http://eprints.um.edu.my/25337/ Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study Ramli, Norlisah Yap, A. Muridan, Roziah Seow, Poh Choo Rahmat, Kartini Fong, Choong Yi Tan, Li Kuo Ong, Lai Choo R Medicine AIM: To evaluate the microstructural abnormalities of the white matter tracts (WMT) using diffusion tensor imaging (DTI) in children with global developmental delay (GDD). MATERIALS AND METHODS: Sixteen children with GDD underwent magnetic resonance imaging (MRI) and cross-sectional DTI. Formal developmental assessment of all GDD patients was performed using the Mullen Scales of Early Learning. An automated processing pipeline for the WMT assessment was implemented. The DTI-derived metrics of the children with GDD were compared to healthy children with normal development (ND). RESULTS: Only two out of the 17 WMT demonstrated significant differences (p<0.05) in DTI parameters between the GDD and ND group. In the uncinate fasciculus (UF), the GDD group had lower mean values for fractional anisotropy (FA; 0.40 versus 0.44), higher values for mean diffusivity (0.96 versus 0.91×10−3 mm2/s) and radial diffusivity (0.75 versus 0.68×10−3 mm2/s) compared to the ND group. In the superior cerebellar peduncle (SCP), mean FA values were lower for the GDD group (0.38 versus 0.40). Normal myelination pattern of DTI parameters was deviated against age for GDD group for UF and SCP. CONCLUSION: The UF and SCP WMT showed microstructural changes suggestive of compromised white matter maturation in children with GDD. The DTI metrics have potential as imaging markers for inadequate white matter maturation in GDD children. © 2019 The Royal College of Radiologists Elsevier 2020 Article PeerReviewed Ramli, Norlisah and Yap, A. and Muridan, Roziah and Seow, Poh Choo and Rahmat, Kartini and Fong, Choong Yi and Tan, Li Kuo and Ong, Lai Choo (2020) Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study. Clinical Radiology, 75 (1). 77.e15-77.e22. ISSN 0009-9260 https://doi.org/10.1016/j.crad.2019.09.134 doi:10.1016/j.crad.2019.09.134 |
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R Medicine Ramli, Norlisah Yap, A. Muridan, Roziah Seow, Poh Choo Rahmat, Kartini Fong, Choong Yi Tan, Li Kuo Ong, Lai Choo Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
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AIM: To evaluate the microstructural abnormalities of the white matter tracts (WMT) using diffusion tensor imaging (DTI) in children with global developmental delay (GDD). MATERIALS AND METHODS: Sixteen children with GDD underwent magnetic resonance imaging (MRI) and cross-sectional DTI. Formal developmental assessment of all GDD patients was performed using the Mullen Scales of Early Learning. An automated processing pipeline for the WMT assessment was implemented. The DTI-derived metrics of the children with GDD were compared to healthy children with normal development (ND). RESULTS: Only two out of the 17 WMT demonstrated significant differences (p<0.05) in DTI parameters between the GDD and ND group. In the uncinate fasciculus (UF), the GDD group had lower mean values for fractional anisotropy (FA; 0.40 versus 0.44), higher values for mean diffusivity (0.96 versus 0.91×10−3 mm2/s) and radial diffusivity (0.75 versus 0.68×10−3 mm2/s) compared to the ND group. In the superior cerebellar peduncle (SCP), mean FA values were lower for the GDD group (0.38 versus 0.40). Normal myelination pattern of DTI parameters was deviated against age for GDD group for UF and SCP. CONCLUSION: The UF and SCP WMT showed microstructural changes suggestive of compromised white matter maturation in children with GDD. The DTI metrics have potential as imaging markers for inadequate white matter maturation in GDD children. © 2019 The Royal College of Radiologists |
format |
Article |
author |
Ramli, Norlisah Yap, A. Muridan, Roziah Seow, Poh Choo Rahmat, Kartini Fong, Choong Yi Tan, Li Kuo Ong, Lai Choo |
author_facet |
Ramli, Norlisah Yap, A. Muridan, Roziah Seow, Poh Choo Rahmat, Kartini Fong, Choong Yi Tan, Li Kuo Ong, Lai Choo |
author_sort |
Ramli, Norlisah |
title |
Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
title_short |
Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
title_full |
Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
title_fullStr |
Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
title_full_unstemmed |
Microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
title_sort |
microstructural abnormalities found in uncinate fasciculus and superior cerebellar tracts in children with global developmental delay: a feasibility study |
publisher |
Elsevier |
publishDate |
2020 |
url |
http://eprints.um.edu.my/25337/ https://doi.org/10.1016/j.crad.2019.09.134 |
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1680857020415082496 |
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13.160551 |