pH-responsive poly(lactic acid)/sodium carboxymethyl cellulose film for enhanced delivery of curcumin in vitro

• Main Authors: Sampath U. Gunathilake, Thennakoon M., Ching, Yern Chee, Chuah, Cheng Hock, Abd Rahman, Noorsaadah, Liou, Nai-Shang
• Format: Article
• Published: Elsevier 2020
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/25165/; https://doi.org/10.1016/j.jddst.2020.101787

Curcumin is a nutraceutical having variety of pharmacological activities including chemopreventive and chemotherapeutic properties. However, it is poorly absorbed after oral administration due to the low solubility, rapid metabolism and pre-systemic metabolic degradation. In this study, poly(lactic...