Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta
The potency, structure-activity relationship, and mechanism of vasorelaxation of a series of flavonoids, representing different subclasses (flavonols: fisetin, rutin, quercetin; flavones: chrysin, flavone, baicalein; flavanones: naringenin, naringin; isoflavones: diadzein and flavanes: epigallo cate...
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my.um.eprints.24632019-12-18T06:11:26Z http://eprints.um.edu.my/2463/ Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta Ajay, M. Gilani, A.H. Mustafa, Mohd Rais R Medicine (General) RM Therapeutics. Pharmacology The potency, structure-activity relationship, and mechanism of vasorelaxation of a series of flavonoids, representing different subclasses (flavonols: fisetin, rutin, quercetin; flavones: chrysin, flavone, baicalein; flavanones: naringenin, naringin; isoflavones: diadzein and flavanes: epigallo catechin gallate), were examined in the isolated rat aorta. Most of the flavonoids tested showed concentration dependent relaxant effects against K +(80 mM) and phenylephrine (PE, 0.1 AM)-induced contractions with a greater inhibition of the responses to the a1-adrenoceptor agonist. The relaxant effects of most of the flavonoids involve in part the release of nitric oxide and prostaglandins from the endothelium as pretreatment with L-NAME and indomethacin attenuated the responses. In addition, the relaxant action of the flavonoids includes inhibition of Ca + 2 influx and release of Ca + 2 from intracellular stores. A structure-activity relationship amongst the flavonoids was suggested. Elsevier 2003 Article PeerReviewed application/pdf en http://eprints.um.edu.my/2463/1/Effects_of_flavonoids_on_vascular_smooth_muscle_of_the_isolated_rat_thoracic_aorta.pdf Ajay, M. and Gilani, A.H. and Mustafa, Mohd Rais (2003) Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sciences, 74 (5). pp. 603-612. ISSN 0024-3205 |
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R Medicine (General) RM Therapeutics. Pharmacology Ajay, M. Gilani, A.H. Mustafa, Mohd Rais Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
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The potency, structure-activity relationship, and mechanism of vasorelaxation of a series of flavonoids, representing different subclasses (flavonols: fisetin, rutin, quercetin; flavones: chrysin, flavone, baicalein; flavanones: naringenin, naringin; isoflavones: diadzein and flavanes: epigallo catechin gallate), were examined in the isolated rat aorta. Most of the flavonoids tested showed concentration dependent relaxant effects against K +(80 mM) and phenylephrine (PE, 0.1 AM)-induced contractions with a greater inhibition of the responses to the
a1-adrenoceptor agonist. The relaxant effects of most of the flavonoids involve in part the release of nitric oxide
and prostaglandins from the endothelium as pretreatment with L-NAME and indomethacin attenuated the responses. In addition, the relaxant action of the flavonoids includes inhibition of Ca + 2 influx and release of Ca + 2
from intracellular stores. A structure-activity relationship amongst the flavonoids was suggested. |
format |
Article |
author |
Ajay, M. Gilani, A.H. Mustafa, Mohd Rais |
author_facet |
Ajay, M. Gilani, A.H. Mustafa, Mohd Rais |
author_sort |
Ajay, M. |
title |
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
title_short |
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
title_full |
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
title_fullStr |
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
title_full_unstemmed |
Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
title_sort |
effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta |
publisher |
Elsevier |
publishDate |
2003 |
url |
http://eprints.um.edu.my/2463/1/Effects_of_flavonoids_on_vascular_smooth_muscle_of_the_isolated_rat_thoracic_aorta.pdf http://eprints.um.edu.my/2463/ |
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1654960586715299840 |
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13.18916 |