Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide
In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially availabl...
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my.um.eprints.246282020-06-04T01:03:18Z http://eprints.um.edu.my/24628/ Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide Zaharani, Lia Khaligh, Nader Ghaffari Shahnavaz, Zohreh Johan, Mohd Rafie QC Physics In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates, and (d) avoid the generation of heavy metal or corrosive waste. © TÜBİTAK TUBITAK 2020 Article PeerReviewed Zaharani, Lia and Khaligh, Nader Ghaffari and Shahnavaz, Zohreh and Johan, Mohd Rafie (2020) Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide. Turkish Journal of Chemistry, 44 (2). pp. 535-542. ISSN 1303-6130 https://doi.org/10.3906/KIM-2002-26 doi:10.3906/KIM-2002-26 |
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QC Physics Zaharani, Lia Khaligh, Nader Ghaffari Shahnavaz, Zohreh Johan, Mohd Rafie Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
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In the current protocol, the arene diazonium saccharin derivatives were initially produced from various substituted aromatic amines; subsequently, these intermediates were treated with a greener organic iodide for the preparation of the aryl iodide. We tried to choose low-cost, commercially available, biodegradable, recoverable, ecofriendly, and safe reagents and solvents. The arene diazonium saccharin intermediates could be stored in the liquid phase into a refrigerator for a long time with no significant loss activity. The outstanding merits of the current protocol (a) included the partial recovering of saccharin and tetraethylammonium salt, (b) reduce the use of solvents and the reaction steps due to eliminating separation and purification of intermediates, (c) good yield of the sterically hindered substrates, and (d) avoid the generation of heavy metal or corrosive waste. © TÜBİTAK |
format |
Article |
author |
Zaharani, Lia Khaligh, Nader Ghaffari Shahnavaz, Zohreh Johan, Mohd Rafie |
author_facet |
Zaharani, Lia Khaligh, Nader Ghaffari Shahnavaz, Zohreh Johan, Mohd Rafie |
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Zaharani, Lia |
title |
Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
title_short |
Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
title_full |
Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
title_fullStr |
Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
title_full_unstemmed |
Arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
title_sort |
arene diazonium saccharin intermediates: a greener and cost-effective alternative method for the preparation of aryl iodide |
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TUBITAK |
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2020 |
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http://eprints.um.edu.my/24628/ https://doi.org/10.3906/KIM-2002-26 |
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13.160551 |