β-Blockers in congestive heart failure

Activation of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology and progression of the disease in chronic heart failure (CHF). Blocking the activation of the RAS with angiotensin converting enzyme inhibitors not only improves symptoms...

Full description

Saved in:
Bibliographic Details
Main Authors: Teh, B.T., Azman, W., Thuraisingham, S., Choy, A.M., Tan, K.H., Jesudason, P., Lang, C.C.
Format: Article
Published: Faculty of Medicine, University of Malaya 1999
Subjects:
Online Access:http://eprints.um.edu.my/24510/
https://jummec.um.edu.my/article/view/4428
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.24510
record_format eprints
spelling my.um.eprints.245102021-03-23T01:34:49Z http://eprints.um.edu.my/24510/ β-Blockers in congestive heart failure Teh, B.T. Azman, W. Thuraisingham, S. Choy, A.M. Tan, K.H. Jesudason, P. Lang, C.C. R Medicine Activation of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology and progression of the disease in chronic heart failure (CHF). Blocking the activation of the RAS with angiotensin converting enzyme inhibitors not only improves symptoms but also prolongs life in symptomatic CHF. Does s similar analogy hold true for the use of B-blockers in CHF? Evidence from a number of small trials and several recent large prospective trials show that B-blocker may improve ventricular function and symptoms in CHF. In a combination of trials investigating the use of carvedilol (an a, and B-blocker) in congestive heart failure a mortality benefit appears to be evident. There are still a number of key question that remain unanswered regarding the tolerability, patient type and stage of CHF in which B-blockers should be advocated. Several large-scale trial are in progress to answer some of these question and also to add further information regarding its efficacy and impact on survivak Faculty of Medicine, University of Malaya 1999 Article PeerReviewed Teh, B.T. and Azman, W. and Thuraisingham, S. and Choy, A.M. and Tan, K.H. and Jesudason, P. and Lang, C.C. (1999) β-Blockers in congestive heart failure. Journal of the University of Malaya Medical Centre (JUMMEC), 4 (1). pp. 26-33. ISSN 1823-7339 https://jummec.um.edu.my/article/view/4428
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Teh, B.T.
Azman, W.
Thuraisingham, S.
Choy, A.M.
Tan, K.H.
Jesudason, P.
Lang, C.C.
β-Blockers in congestive heart failure
description Activation of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology and progression of the disease in chronic heart failure (CHF). Blocking the activation of the RAS with angiotensin converting enzyme inhibitors not only improves symptoms but also prolongs life in symptomatic CHF. Does s similar analogy hold true for the use of B-blockers in CHF? Evidence from a number of small trials and several recent large prospective trials show that B-blocker may improve ventricular function and symptoms in CHF. In a combination of trials investigating the use of carvedilol (an a, and B-blocker) in congestive heart failure a mortality benefit appears to be evident. There are still a number of key question that remain unanswered regarding the tolerability, patient type and stage of CHF in which B-blockers should be advocated. Several large-scale trial are in progress to answer some of these question and also to add further information regarding its efficacy and impact on survivak
format Article
author Teh, B.T.
Azman, W.
Thuraisingham, S.
Choy, A.M.
Tan, K.H.
Jesudason, P.
Lang, C.C.
author_facet Teh, B.T.
Azman, W.
Thuraisingham, S.
Choy, A.M.
Tan, K.H.
Jesudason, P.
Lang, C.C.
author_sort Teh, B.T.
title β-Blockers in congestive heart failure
title_short β-Blockers in congestive heart failure
title_full β-Blockers in congestive heart failure
title_fullStr β-Blockers in congestive heart failure
title_full_unstemmed β-Blockers in congestive heart failure
title_sort β-blockers in congestive heart failure
publisher Faculty of Medicine, University of Malaya
publishDate 1999
url http://eprints.um.edu.my/24510/
https://jummec.um.edu.my/article/view/4428
_version_ 1695531087828090880
score 13.18916