Defining a threshold for tacrolimus intra-patient variability associated with late acute cellular rejection in paediatric kidney transplant recipients

• Main Authors: Abu Bakar, Karmila, Mohamad, Nor Asiah, Hodi, Zsolt, McCulloch, Tom, Williams, Alun, Christian, Martin, Key, Tim, Kim, Jon Jin
• Format: Article
• Published: Springer Verlag 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/24292/; https://doi.org/10.1007/s00467-019-04346-z

Background: Late acute cellular rejection (LACR) is associated with poorer graft outcomes and non-adherence. Non-adherence to tacrolimus can be indirectly assessed by the intra-patient variability (IPV) of tacrolimus trough levels. The threshold of IPV associated with rejection is not known. Methods...