Synthesis, cytotoxicity and antineoplastic activities of novel acridine-based platinum(II) organometallic complexes

• Main Authors: Ismail, Nur Amajeida, Salman, Abbas Abdulameer, Mohd Yusof, Mohd Sukeri, Che Soh, Siti Kamilah, Kadir Pahirulzaman, Khomaizon Abdul, Ali, Hapipah Mohd, Sarip, Rozie
• Format: Article
• Published: Elsevier 2019
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/24099/; https://doi.org/10.1016/j.jorganchem.2019.06.024

Two new platinum(II) complexes incorporating acridine ligands with aniline moieties were successfully synthesised and characterised. The acridine-based ligands were synthesised by means of Ullmann's condensation. The reaction of cis-[PtCl2(DMSO)2] with the aforementioned ligand in a specified m...