Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies

• Main Authors: Muhammad, Akhtar, Khan, Behramand, Iqbal, Zafar, Khan, Amir Zada, Khan, Inamullah, Khan, Kashif, Alamzeb, Muhammad, Ahmad, Nasir, Khan, Khalid, Lal Badshah, Syed, Ullah, Asad, Muhammad, Sayyar, Jan, Muhammad Tariq, Nadeem, Said, Kabir, Nurul
• Format: Article
• Published: American Chemical Society 2019
• Subjects: Q Science (General); QD Chemistry; QH Natural history
• Online Access: http://eprints.um.edu.my/23951/; https://doi.org/10.1021/acsomega.9b01041

The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (...