Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population
Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Ma...
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my.um.eprints.239392021-07-26T02:45:53Z http://eprints.um.edu.my/23939/ Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population Ab Mumin, Nazimah Rahmat, Kartini Fadzli, Farhana Ramli, Marlina Tanty Westerhout, Caroline Judy Ramli, Norlisah Rozalli, Faizatul Izza Ng, Kwan Hoong R Medicine Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Malaysian population. FFDM and C-View images (n = 380) were independently evaluated by three readers through Breast Imaging Reporting and Data System (BI-RADS) categorisation, breast density and lesion characterisation. Statistical analysis was done comparing sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of C-View + DBT with FFDM + DBT as standard of reference. Very good interreader agreement in BI-RADS category and density assessment between C-View + DBT and FFDM + DBT, with high sensitivity, specificity, PPV and NPV of C-View + DBT when compared with FFDM + DBT. There was comparable PPV between C-View + DBT and FFDM + DBT, with histopathology as gold standard. High level of interreader agreement in BI-RADS category and density assessment for FFDM + DBT and C-View + DBT. There was good agreement between FFDM + DBT and C-View + DBT in mass characterization, and almost perfect agreement in calcification and asymmetric density. 52.2% lower radiation dose incurred when using C-View + DBT. Hence, synthesized 2D images are comparable to FFDM with reduction in radiation dose within the limits of Malaysian multi-ethnic population. © 2019, The Author(s). Nature Research 2019 Article PeerReviewed Ab Mumin, Nazimah and Rahmat, Kartini and Fadzli, Farhana and Ramli, Marlina Tanty and Westerhout, Caroline Judy and Ramli, Norlisah and Rozalli, Faizatul Izza and Ng, Kwan Hoong (2019) Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population. Scientific Reports, 9 (1). p. 1459. ISSN 2045-2322 https://doi.org/10.1038/s41598-018-37451-4 doi:10.1038/s41598-018-37451-4 |
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R Medicine Ab Mumin, Nazimah Rahmat, Kartini Fadzli, Farhana Ramli, Marlina Tanty Westerhout, Caroline Judy Ramli, Norlisah Rozalli, Faizatul Izza Ng, Kwan Hoong Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population |
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Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Malaysian population. FFDM and C-View images (n = 380) were independently evaluated by three readers through Breast Imaging Reporting and Data System (BI-RADS) categorisation, breast density and lesion characterisation. Statistical analysis was done comparing sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of C-View + DBT with FFDM + DBT as standard of reference. Very good interreader agreement in BI-RADS category and density assessment between C-View + DBT and FFDM + DBT, with high sensitivity, specificity, PPV and NPV of C-View + DBT when compared with FFDM + DBT. There was comparable PPV between C-View + DBT and FFDM + DBT, with histopathology as gold standard. High level of interreader agreement in BI-RADS category and density assessment for FFDM + DBT and C-View + DBT. There was good agreement between FFDM + DBT and C-View + DBT in mass characterization, and almost perfect agreement in calcification and asymmetric density. 52.2% lower radiation dose incurred when using C-View + DBT. Hence, synthesized 2D images are comparable to FFDM with reduction in radiation dose within the limits of Malaysian multi-ethnic population. © 2019, The Author(s). |
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Article |
author |
Ab Mumin, Nazimah Rahmat, Kartini Fadzli, Farhana Ramli, Marlina Tanty Westerhout, Caroline Judy Ramli, Norlisah Rozalli, Faizatul Izza Ng, Kwan Hoong |
author_facet |
Ab Mumin, Nazimah Rahmat, Kartini Fadzli, Farhana Ramli, Marlina Tanty Westerhout, Caroline Judy Ramli, Norlisah Rozalli, Faizatul Izza Ng, Kwan Hoong |
author_sort |
Ab Mumin, Nazimah |
title |
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population |
title_short |
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population |
title_full |
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population |
title_fullStr |
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population |
title_full_unstemmed |
Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population |
title_sort |
diagnostic efficacy of synthesized 2d digital breast tomosynthesis in multi-ethnic malaysian population |
publisher |
Nature Research |
publishDate |
2019 |
url |
http://eprints.um.edu.my/23939/ https://doi.org/10.1038/s41598-018-37451-4 |
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1706957588782907392 |
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13.187195 |