Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks

• Main Authors: Walters, Kevin, Sarsenov, Radmir, Too, Wen Siong, Hare, Roseanna K., Paterson, Ian Charles, Lambert, Daniel W., Brown, Stephen, Bradford, James R.
• Format: Article
• Language: English
• Published: BioMed Central 2019
• Subjects: R Medicine; RC Internal medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/23891/1/s12864-019-5850-7; http://eprints.um.edu.my/23891/; https://doi.org/10.1186/s12864-019-5850-7

Background: Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of cellular processes in diseases such as cancer, although the functions of most remain poorly understood. To address this, here we apply a novel strategy to integrate gene expression profiles across 32 cancer types, and c...