The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain
Dental pain is a common health problem that negatively impacts the activities of daily living. Dentine hypersensitivity and pulpitis-associated pain are among the most common types of dental pain. Patients with these conditions feel pain upon exposure of the affected tooth to various external stimul...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI
2019
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/23883/1/ijms-20-00526%20%281%29.pdf http://eprints.um.edu.my/23883/ https://doi.org/10.3390/ijms20030526 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.23883 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.238832020-02-21T02:17:52Z http://eprints.um.edu.my/23883/ The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain Hossain, Mohammad Zakir Bakri, Marina Mohd Yahya, Farhana Ando, Hiroshi Unno, Shumpei Kitagawa, Junichi RK Dentistry Practice of dentistry. Dental economics Dental pain is a common health problem that negatively impacts the activities of daily living. Dentine hypersensitivity and pulpitis-associated pain are among the most common types of dental pain. Patients with these conditions feel pain upon exposure of the affected tooth to various external stimuli. However, the molecular mechanisms underlying dental pain, especially the transduction of external stimuli to electrical signals in the nerve, remain unclear. Numerous ion channels and receptors localized in the dental primary afferent neurons (DPAs) and odontoblasts have been implicated in the transduction of dental pain, and functional expression of various polymodal transient receptor potential (TRP) channels has been detected in DPAs and odontoblasts. External stimuli-induced dentinal tubular fluid movement can activate TRP channels on DPAs and odontoblasts. The odontoblasts can in turn activate the DPAs by paracrine signaling through ATP and glutamate release. In pulpitis, inflammatory mediators may sensitize the DPAs. They could also induce post-translational modifications of TRP channels, increase trafficking of these channels to nerve terminals, and increase the sensitivity of these channels to stimuli. Additionally, in caries-induced pulpitis, bacterial products can directly activate TRP channels on DPAs. In this review, we provide an overview of the TRP channels expressed in the various tooth structures, and we discuss their involvement in the development of dental pain. MDPI 2019 Article PeerReviewed text en http://eprints.um.edu.my/23883/1/ijms-20-00526%20%281%29.pdf Hossain, Mohammad Zakir and Bakri, Marina Mohd and Yahya, Farhana and Ando, Hiroshi and Unno, Shumpei and Kitagawa, Junichi (2019) The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain. International Journal of Molecular Sciences, 20 (3). p. 526. ISSN 1661-6596 https://doi.org/10.3390/ijms20030526 doi:10.3390/ijms20030526 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
language |
English |
topic |
RK Dentistry Practice of dentistry. Dental economics |
spellingShingle |
RK Dentistry Practice of dentistry. Dental economics Hossain, Mohammad Zakir Bakri, Marina Mohd Yahya, Farhana Ando, Hiroshi Unno, Shumpei Kitagawa, Junichi The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
description |
Dental pain is a common health problem that negatively impacts the activities of daily living. Dentine hypersensitivity and pulpitis-associated pain are among the most common types of dental pain. Patients with these conditions feel pain upon exposure of the affected tooth to various external stimuli. However, the molecular mechanisms underlying dental pain, especially the transduction of external stimuli to electrical signals in the nerve, remain unclear. Numerous ion channels and receptors localized in the dental primary afferent neurons (DPAs) and odontoblasts have been implicated in the transduction of dental pain, and functional expression of various polymodal transient receptor potential (TRP) channels has been detected in DPAs and odontoblasts. External stimuli-induced dentinal tubular fluid movement can activate TRP channels on DPAs and odontoblasts. The odontoblasts can in turn activate the DPAs by paracrine signaling through ATP and glutamate release. In pulpitis, inflammatory mediators may sensitize the DPAs. They could also induce post-translational modifications of TRP channels, increase trafficking of these channels to nerve terminals, and increase the sensitivity of these channels to stimuli. Additionally, in caries-induced pulpitis, bacterial products can directly activate TRP channels on DPAs. In this review, we provide an overview of the TRP channels expressed in the various tooth structures, and we discuss their involvement in the development of dental pain. |
format |
Article |
author |
Hossain, Mohammad Zakir Bakri, Marina Mohd Yahya, Farhana Ando, Hiroshi Unno, Shumpei Kitagawa, Junichi |
author_facet |
Hossain, Mohammad Zakir Bakri, Marina Mohd Yahya, Farhana Ando, Hiroshi Unno, Shumpei Kitagawa, Junichi |
author_sort |
Hossain, Mohammad Zakir |
title |
The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
title_short |
The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
title_full |
The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
title_fullStr |
The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
title_full_unstemmed |
The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain |
title_sort |
role of transient receptor potential (trp) channels in the transduction of dental pain |
publisher |
MDPI |
publishDate |
2019 |
url |
http://eprints.um.edu.my/23883/1/ijms-20-00526%20%281%29.pdf http://eprints.um.edu.my/23883/ https://doi.org/10.3390/ijms20030526 |
_version_ |
1662755192564613120 |
score |
13.18916 |