Chitosan complexed carboxymethylated iota-carrageenan oral insulin particles: Stability, permeability and in vivo evaluation

• Main Authors: Sahoo, Pratyusa, Leong, Kok Hoong, Nyamathulla, Shaik, Onuki, Yoshinori, Takayama, Kozo, Chung, Lip Yong
• Format: Article
• Published: Elsevier 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23586/; https://doi.org/10.1016/j.mtcomm.2019.100557

We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo stu...