N-(2-hydroxyphenyl)acetamide and its gold nanoparticle conjugation prevent glycerol-induced acute kidney injury by attenuating inflammation and oxidative injury in mice

• Main Authors: Siddiqui, Rehan Ahmed, Simjee, Shabana Usman, Kabir, Nurul, Ateeq, Muhammad, Shah, M. Raza, Hussain, Syed Saad
• Format: Article
• Published: Springer 2019
• Subjects: Q Science (General); QD Chemistry; QH Natural history; QR Microbiology
• Online Access: http://eprints.um.edu.my/23436/; https://doi.org/10.1007/s11010-018-3371-3

The protective activity of N-(2-hydroxyphenyl)acetamide (NA-2) and NA-2-coated gold nanoparticles (NA-2-AuNPs) in glycerol-treated model of acute kidney injury (AKI) in mice was investigated. NA-2 (50 mg/kg) and NA-2-AuNPs (30 mg/kg) were given to the animals for four days followed by 24-h water dep...