Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice

• Main Authors: Shimizu, Hiroyuki, Tee, Han Kang, Tan, Chee Wah, Yogarajah, Thinesshwary, Lee, Michelle Hui Pheng, Chai, Hann Juang, Hanapi, Nur Aziah, Yusof, Siti R., Ong, Kien Chai, Lee, Vannajan Sanghiran, Sam, I-Ching, Chan, Yoke Fun
• Format: Article
• Published: Public Library of Science 2019
• Subjects: Q Science (General); QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/23268/; https://doi.org/10.1371/journal.ppat.1007863

Enterovirus A71 (EV-A71) causes hand, foot and mouth disease epidemics with neurological complications and fatalities. However, the neuropathogenesis of EV-A71 remains poorly understood. In mice, adaptation and virulence determinants have been mapped to mutations at VP2-149, VP1-145 and VP1-244. We...