Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization

• Main Authors: Thavoncharoensub, Ninticha, Maruyama, Kento, Heh, Choon Han, Leong, Kok Hoong, Shi, Hui, Shigematsu, Yoshiharu, Sasaki, Shigeki, Taniguchi, Yosuke
• Format: Article
• Published: Taylor & Francis 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23245/; https://doi.org/10.1080/15257770.2019.1586919

8-OxodGTP is generated by the reaction between dGTP and reactive oxygen species and a considered mutagenic nucleotide. It can be incorporated into the duplex DNA during replication processes by the DNA polymerase, and thus the repair enzyme removes oxodGTP from the nucleotide pools in living cells....