A bioactive injectable bulking material; a potential therapeutic approach for stress urinary incontinence

• Main Authors: Vardar, E., Vythilingam, Ganesh, Pinnagoda, K., Engelhardt, E.M., Zambelli, P.Y., Hubbell, J.A., Lutolf, M.P., Frey, P., Larsson, H.M.
• Format: Article
• Published: Elsevier 2019
• Subjects: R Medicine; TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/23206/; https://doi.org/10.1016/j.biomaterials.2019.03.030

Stress urinary incontinence (SUI) is a life changing condition, affecting 20 million women worldwide. In this study, we developed a bioactive, injectable bulking agent that consists of Permacol™ (Medtronic, Switzerland) and recombinant insulin like growth factor-1 conjugated fibrin micro-beads (fib_...