SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1

• Main Authors: Zhang, H., Xu, Y., Filipovic, A., Lit, Lei Cheng, Koo, C.Y., Stebbing, J., Giamas, G.
• Format: Article
• Published: Springer Nature 2013
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23075/; https://doi.org/10.1038/bjc.2013.628

Background:We have previously identified kinase suppressor of ras-1 (KSR1) as a potential regulatory gene in breast cancer. KSR1, originally described as a novel protein kinase, has a role in activation of mitogen-activated protein kinases. Emerging evidence has shown that KSR1 may have dual functio...