Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

• Main Authors: Zhang, Yaqing, Yan, Wei, Collins, Meredith A., Bednar, Filip, Rakshit, Sabita, Zetter, Bruce R., Stanger, Ben Z., Chung, Ivy, Rhim, Andrew D., di Magliano, Marina Pasca
• Format: Article
• Published: American Association for Cancer Research 2013
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23073/; https://doi.org/10.1158/0008-5472.CAN-13-1558-T

Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the pancreas recapitulate the stepwise progression of the human disease. The inflammatory cytokine interleukin (IL)-6 is often...