Global Disparities in Breast Cancer Genetics Testing, Counselling and Management

• Main Authors: Yip, Cheng Har, Evans, Dolores Gareth, Agarwal, Gaurav, Buccimazza, Ines, Kwong, Ava, Morant, R., Prakash, Ipshita, Song, C.Y., Mohd Taib, Nur Aishah, Tausch, Christoph, Ung, Owen, Meterissian, Sarkis
• Format: Article
• Published: Springer Verlag (Germany) 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22964/; https://doi.org/10.1007/s00268-018-04897-6

Hereditary breast cancers, mainly due to BRCA1 and BRCA2 mutations, account for only 5–10% of this disease. The threshold for genetic testing is a 10% likelihood of detecting a mutation, as determined by validated models such as BOADICEA and Manchester Scoring System. A 90–95% reduction in breast ca...