Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies

• Main Authors: Voon, Siew Hui, Kue, Chin Siang, Imae, Toyoko, Saw, Wen Shang, Lee, Hong Boon, Kiew, Lik Voon, Chung, Lip Yong, Yusa, Shin-ichi
• Format: Article
• Published: Elsevier 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22841/; https://doi.org/10.1016/j.ijpharm.2017.10.023

Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in co...