Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro
This study evaluates the in vitro inhibition of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) by Pleurotus pulmonarius extracts. The protective effect on the endothelial membrane against oxidative stress through the protection of nitric oxide bioav...
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my.um.eprints.227302019-10-14T03:21:07Z http://eprints.um.edu.my/22730/ Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro Abidin, Mohamad Hamdi Zainal Abdullah, Noorlidah Abidin, Nurhayati Zainal Q Science (General) QH Natural history This study evaluates the in vitro inhibition of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) by Pleurotus pulmonarius extracts. The protective effect on the endothelial membrane against oxidative stress through the protection of nitric oxide bioavailability, as well as inhibition of endocan expression, was evaluated using human aortic endothelial cells (HAECs). Crude cold aqueous extract exhibited the most potent inhibitory activities against ACE and HMG-CoA reductase, with 61.79% and 44.30% inhibition, respectively. It also protected the bioavailability of NO released by HAECs, with 84.88% cell viability. The crude hot water extract was the most potent in inhibiting endocan expression, with 18.61% inhibition. Begell House 2018 Article PeerReviewed Abidin, Mohamad Hamdi Zainal and Abdullah, Noorlidah and Abidin, Nurhayati Zainal (2018) Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro. International Journal of Medicinal Mushrooms, 20 (3). pp. 283-290. ISSN 1521-9437 https://doi.org/10.1615/IntJMedMushrooms.2018025821 doi:10.1615/IntJMedMushrooms.2018025821 |
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Q Science (General) QH Natural history Abidin, Mohamad Hamdi Zainal Abdullah, Noorlidah Abidin, Nurhayati Zainal Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro |
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This study evaluates the in vitro inhibition of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) by Pleurotus pulmonarius extracts. The protective effect on the endothelial membrane against oxidative stress through the protection of nitric oxide bioavailability, as well as inhibition of endocan expression, was evaluated using human aortic endothelial cells (HAECs). Crude cold aqueous extract exhibited the most potent inhibitory activities against ACE and HMG-CoA reductase, with 61.79% and 44.30% inhibition, respectively. It also protected the bioavailability of NO released by HAECs, with 84.88% cell viability. The crude hot water extract was the most potent in inhibiting endocan expression, with 18.61% inhibition. |
format |
Article |
author |
Abidin, Mohamad Hamdi Zainal Abdullah, Noorlidah Abidin, Nurhayati Zainal |
author_facet |
Abidin, Mohamad Hamdi Zainal Abdullah, Noorlidah Abidin, Nurhayati Zainal |
author_sort |
Abidin, Mohamad Hamdi Zainal |
title |
Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro |
title_short |
Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro |
title_full |
Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro |
title_fullStr |
Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro |
title_full_unstemmed |
Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro |
title_sort |
antiatherogenic potential of extracts from the gray oyster medicinal mushroom, pleurotus pulmonarius (agaricomycetes), in vitro |
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Begell House |
publishDate |
2018 |
url |
http://eprints.um.edu.my/22730/ https://doi.org/10.1615/IntJMedMushrooms.2018025821 |
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1648736194183299072 |
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13.160551 |