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The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves

Leaves from three varieties of Ficus deltoidea, colloquially termed small-(FDS), medium-(FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid content, antioxidant activity, and cyt...

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Main Authors: Abrahim, Noor Nazirahanie, Abdul-Rahman, Puteri Shafinaz, Aminudin, Norhaniza
Format: Article
Published: PeerJ 2018
Subjects:
Q Science (General)
QH Natural history
R Medicine
Online Access:http://eprints.um.edu.my/22722/
https://doi.org/10.7717/peerj.5694
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spelling my.um.eprints.227222019-10-14T02:24:04Z http://eprints.um.edu.my/22722/ The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves Abrahim, Noor Nazirahanie Abdul-Rahman, Puteri Shafinaz Aminudin, Norhaniza Q Science (General) QH Natural history R Medicine Leaves from three varieties of Ficus deltoidea, colloquially termed small-(FDS), medium-(FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid content, antioxidant activity, and cytotoxicity of the fractions were investigated. The EAF had the highest phenolic and flavonoid content compared to the other FDS fractions. Conversely, the FDM crude extract had the highest phenolic and flavonoid content compared to the otherFDMsamples. Antioxidant activity was highest in the FDB crude extract. Ultra-high-performance liquid chromatography showed that two compounds, vitexin and coumaric acid, were present in the FDB crude extract. Additionally, the F. deltoidea leaves caused no signs of toxicity in a normal liver cell line. Our findings show that F. deltoidea varieties have excellent antioxidant activity with no cytotoxic effects on normal liver cells. PeerJ 2018 Article PeerReviewed Abrahim, Noor Nazirahanie and Abdul-Rahman, Puteri Shafinaz and Aminudin, Norhaniza (2018) The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves. PeerJ, 6. e5694. ISSN 2167-8359 https://doi.org/10.7717/peerj.5694 doi:10.7717/peerj.5694
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QH Natural history
R Medicine
spellingShingle Q Science (General)
QH Natural history
R Medicine
Abrahim, Noor Nazirahanie
Abdul-Rahman, Puteri Shafinaz
Aminudin, Norhaniza
The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves
description Leaves from three varieties of Ficus deltoidea, colloquially termed small-(FDS), medium-(FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid content, antioxidant activity, and cytotoxicity of the fractions were investigated. The EAF had the highest phenolic and flavonoid content compared to the other FDS fractions. Conversely, the FDM crude extract had the highest phenolic and flavonoid content compared to the otherFDMsamples. Antioxidant activity was highest in the FDB crude extract. Ultra-high-performance liquid chromatography showed that two compounds, vitexin and coumaric acid, were present in the FDB crude extract. Additionally, the F. deltoidea leaves caused no signs of toxicity in a normal liver cell line. Our findings show that F. deltoidea varieties have excellent antioxidant activity with no cytotoxic effects on normal liver cells.
format Article
author Abrahim, Noor Nazirahanie
Abdul-Rahman, Puteri Shafinaz
Aminudin, Norhaniza
author_facet Abrahim, Noor Nazirahanie
Abdul-Rahman, Puteri Shafinaz
Aminudin, Norhaniza
author_sort Abrahim, Noor Nazirahanie
title The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves
title_short The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves
title_full The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves
title_fullStr The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves
title_full_unstemmed The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves
title_sort antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of ficus deltoidea leaves
publisher PeerJ
publishDate 2018
url http://eprints.um.edu.my/22722/
https://doi.org/10.7717/peerj.5694
_version_ 1648736191855460352
score 13.209306

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