Effect of pioglitazone on vasopressor responses to adrenergic agonists and angiotensin II in diabetic and non-diabetic spontaneously hypertensive rats

• Main Authors: Afzal, Sheryar, Sattar, Munavvar Abdul, Akhtar, Safia, Abdullah, Nor Azizan, Eseyin, Olorunfemi A., Abdulla, Mohammed H., Johns, Edward James
• Format: Article
• Published: Faculty of Pharmacy, University of Karachi 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/22693/; http://www.pjps.pk/wp-content/uploads/pdfs/31/3/Paper-3.pdf

Pioglitazone, peroxisome proliferator-activated receptor (PPAR-γ) agonist, is a therapeutic drug for diabetes. Present study investigated the interaction between PPAR-γ and alpha adrenoceptors in modulating vasopressor responses to Angiotensin II (Ang II) and adrenergic agonists, in diabetic & n...