Rheological behavior of biodegradable N -succinyl chitosan- g -poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

• Main Authors: Bashir, Shahid, Teo, Yin Yin, Ramesh, Subramaniam, Ramesh, Kasi, Mushtaq, Muhammad Waheed
• Format: Article
• Published: Elsevier 2018
• Subjects: Q Science (General); QC Physics; QD Chemistry
• Online Access: http://eprints.um.edu.my/22342/; https://doi.org/10.1016/j.ijbiomac.2018.05.182

Novel pH sensitive N-succinyl chitosan-g-poly (acrylic acid) hydrogels were synthesized through free radical mechanism. Rheometer was used to observe the mechanical strength of the hydrogels. In vitro degradation was conducted in SIF (pH 7.4). The effect of concentration of monomers, initiator, and...