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Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report

Phenytoin is a widely prescribed antiepileptic agent for both focal and generalized seizure. We report a case of a 20-year-old man with focal epilepsy presented with acute bilateral visual loss, and delirium. His random phenytoin serum concentration on admission was 43.6 mg/L, well above the recomme...

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Main Authors: Chew, Sin Hong, Looi, Irene, Lo, Yoke Lin, Lim, Kheng Seang
Format: Article
Published: ASEAN Neurological Association 2018
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/22226/
https://www.neurology-asia.org/articles/neuroasia-2018-23(4)-363.pdf
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spelling my.um.eprints.222262019-09-04T07:31:13Z http://eprints.um.edu.my/22226/ Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report Chew, Sin Hong Looi, Irene Lo, Yoke Lin Lim, Kheng Seang R Medicine Phenytoin is a widely prescribed antiepileptic agent for both focal and generalized seizure. We report a case of a 20-year-old man with focal epilepsy presented with acute bilateral visual loss, and delirium. His random phenytoin serum concentration on admission was 43.6 mg/L, well above the recommended therapeutic range of 10-20 mg/L. Extensive investigations have ruled out other vascular or demyelinating causes. His visual symptoms completely resolved after discontinuing phenytoin for 84 hours. This case shows that acute phenytoin toxicity can result in reversible visual failure. ASEAN Neurological Association 2018 Article PeerReviewed Chew, Sin Hong and Looi, Irene and Lo, Yoke Lin and Lim, Kheng Seang (2018) Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report. Neurology Asia, 23 (4). pp. 363-365. ISSN 1823-6138 https://www.neurology-asia.org/articles/neuroasia-2018-23(4)-363.pdf
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Chew, Sin Hong
Looi, Irene
Lo, Yoke Lin
Lim, Kheng Seang
Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
description Phenytoin is a widely prescribed antiepileptic agent for both focal and generalized seizure. We report a case of a 20-year-old man with focal epilepsy presented with acute bilateral visual loss, and delirium. His random phenytoin serum concentration on admission was 43.6 mg/L, well above the recommended therapeutic range of 10-20 mg/L. Extensive investigations have ruled out other vascular or demyelinating causes. His visual symptoms completely resolved after discontinuing phenytoin for 84 hours. This case shows that acute phenytoin toxicity can result in reversible visual failure.
format Article
author Chew, Sin Hong
Looi, Irene
Lo, Yoke Lin
Lim, Kheng Seang
author_facet Chew, Sin Hong
Looi, Irene
Lo, Yoke Lin
Lim, Kheng Seang
author_sort Chew, Sin Hong
title Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
title_short Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
title_full Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
title_fullStr Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
title_full_unstemmed Phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
title_sort phenytoin toxicity presenting with acute visual loss and acute delirium, a case report
publisher ASEAN Neurological Association
publishDate 2018
url http://eprints.um.edu.my/22226/
https://www.neurology-asia.org/articles/neuroasia-2018-23(4)-363.pdf
_version_ 1646210180368564224
score 13.188404

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