Synthesis of 1,3-benzoxazines Based on 2,4,4-trimethyl-7,2’,4’-trihydroxy Flavan: Antibacterial, Anti-inflammatory, Cyclooxygenase-2 Inhibition and Molecular Modelling Studies

• Main Authors: Mohammed, Issam Ahmed, Ahmed, Mahmood, Ikram, Rabia, Muddassar, Muhammad, Qadir, Muhammad Abdul, Awang, Khalijah
• Format: Article
• Published: Bentham Science Publishers 2018
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/21246/; https://doi.org/10.2174/1570180815666180420100922

Background: In the present study, the formation of 2, 4, 4-trimethyl-7,2’4’-trihydroxy flavan has been used as the key feature for the formation of new 1,3-benzoxazines. This reaction was carried out via Mannich-condensation reaction, the 7-hydroxy group of flavan was reacted with different primary...