Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

• Main Authors: Nyon, Mun Peak, Du, Lanying, Tseng, Chien Te Kent, Seid, Christopher A., Pollet, Jeroen, Naceanceno, Kevin S., Agrawal, Anurodh, Algaissi, Abdullah, Peng, Bi Hung, Tai, Wanbo, Jiang, Shibo, Bottazzi, Maria Elena, Strych, Ulrich, Hotez, Peter J.
• Format: Article
• Published: Elsevier 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/21091/; https://doi.org/10.1016/j.vaccine.2018.02.065

Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 2040 patients and caused 712 deaths since its first appearance in 2012, yet neither pathogen-specific therapeutics nor approved vaccines are available. To address this need, we are developing a subunit recombinant protein...