Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives
Bio-functional proteins from microalgae have numerous biological properties with health-promoting effects. However, efficient harnessing of bio-functional proteins from microalgae is still in its infancy. One of the major obstacles that hinder the mass production of bio-functional proteins is the pr...
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my.um.eprints.210262020-06-16T01:54:40Z http://eprints.um.edu.my/21026/ Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives Phong, Win Nee Show, Pau Loke Ling, Tau Chuan Juan, Joon Ching Ng, Eng Poh Chang, Jo-Shu Q Science (General) QH Natural history Bio-functional proteins from microalgae have numerous biological properties with health-promoting effects. However, efficient harnessing of bio-functional proteins from microalgae is still in its infancy. One of the major obstacles that hinder the mass production of bio-functional proteins is the presence of resistant cell wall that diminishes the liberation of cell contents. As the bio-functional proteins are very sensitive to denaturation, selecting a mild disruption method to rupture the cell wall, while preserving their bioactivity and functionality, is of vital importance in downstream processing. To ensure the future development of efficient mild disruption methods for maximum recovery of bio-functional proteins from microalgae, this review provides useful information on various mild disruption approaches, current status, potential technologies that are still under development, as well as their advantages and constraints. In particular, those potential technologies that require further attention in the future (namely, explosive decompression, microfluidization, pulsed arc technology and cationic polymer coated membranes) are also discussed in this review. Elsevier 2018 Article PeerReviewed Phong, Win Nee and Show, Pau Loke and Ling, Tau Chuan and Juan, Joon Ching and Ng, Eng Poh and Chang, Jo-Shu (2018) Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives. Algal Research, 31. pp. 506-516. ISSN 2211-9264 https://doi.org/10.1016/j.algal.2017.04.005 doi:10.1016/j.algal.2017.04.005 |
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Q Science (General) QH Natural history Phong, Win Nee Show, Pau Loke Ling, Tau Chuan Juan, Joon Ching Ng, Eng Poh Chang, Jo-Shu Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives |
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Bio-functional proteins from microalgae have numerous biological properties with health-promoting effects. However, efficient harnessing of bio-functional proteins from microalgae is still in its infancy. One of the major obstacles that hinder the mass production of bio-functional proteins is the presence of resistant cell wall that diminishes the liberation of cell contents. As the bio-functional proteins are very sensitive to denaturation, selecting a mild disruption method to rupture the cell wall, while preserving their bioactivity and functionality, is of vital importance in downstream processing. To ensure the future development of efficient mild disruption methods for maximum recovery of bio-functional proteins from microalgae, this review provides useful information on various mild disruption approaches, current status, potential technologies that are still under development, as well as their advantages and constraints. In particular, those potential technologies that require further attention in the future (namely, explosive decompression, microfluidization, pulsed arc technology and cationic polymer coated membranes) are also discussed in this review. |
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Article |
author |
Phong, Win Nee Show, Pau Loke Ling, Tau Chuan Juan, Joon Ching Ng, Eng Poh Chang, Jo-Shu |
author_facet |
Phong, Win Nee Show, Pau Loke Ling, Tau Chuan Juan, Joon Ching Ng, Eng Poh Chang, Jo-Shu |
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Phong, Win Nee |
title |
Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives |
title_short |
Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives |
title_full |
Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives |
title_fullStr |
Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives |
title_full_unstemmed |
Mild cell disruption methods for bio-functional proteins recovery from microalgae—Recent developments and future perspectives |
title_sort |
mild cell disruption methods for bio-functional proteins recovery from microalgae—recent developments and future perspectives |
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Elsevier |
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2018 |
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http://eprints.um.edu.my/21026/ https://doi.org/10.1016/j.algal.2017.04.005 |
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