Hepatoprotectivity of Panduratin A against liver damage: In vivo demonstration with a rat model of cirrhosis induced by thioacetamide

• Main Authors: Salama, Suzy Munir, Ibrahim, Ibrahim Abdel Aziz, Shahzad, Naiyer, Al-Ghamdi, Saeed, Ayoub, Nahla, AlRashdi, Ahmed Salim, Abdulla, Mahmood Ameen, Salehen, Nur'ain, Bilgen, Mehmet
• Format: Article
• Published: Wiley 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/20805/; https://doi.org/10.1111/apm.12878

This experiment evaluated Panduratin A (PA), a chalcone isolated from Boesenbergia rotunda rhizomes, for its hepatoprotectivity. Rats were subjected to liver damage induced by intra-peritoneal injection of thioacetamide (TAA). PA was tested first for its acute toxicity and then administered by oral...