Deciphering critical amino acid residues to modify and enhance the binding affinity of ankyrin scaffold specific to capsid protein of human immunodeficiency virus type 1

• Main Authors: Saoin, Somphot, Wisitponchai, Tanchanok, Intachai, Kannaporn, Chupradit, Koollawat, Moonmuang, Sutpirat, Nangola, Sawitree, Kitidee, Kuntida, Fanhchaksai, Kanda, Lee, Vannajan Sanghiran, Hong, Saw See, Boulanger, Pierre, Chuankhayan, Phimonphan, Chen, Chun Jung, Tayapiwatana, Chatchai
• Format: Article
• Published: Allergy and Immunology Society of Thailand 2017
• Subjects: Q Science (General); QC Physics; QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/20771/; https://doi.org/10.12932/AP-280217-0037

Background: Ank GAG 1D4 is an artificial ankyrin repeat protein which recognizes the capsid protein (CA) of the human immunodeficiency virus type 1 (HIV-1) and exhibits the intracellular antiviral activity on the viral assembly process. Improving the binding affinity of Ank GAG 1D4 would potentially...