Zebrafish embryonic development-interfering macrolides from Streptomyces californicus impact growth and mitochondrial function in human colorectal cancer cells

• Main Authors: Tan, Pei Jean, Lau, Beng Fye, Krishnasamy, Getha, Ng, Mei Fong, Husin, Lili Sahira, Ruslan, Nur Faizah, Song, D.S.S., Velaithan, Vithya, Okuda, Kazuhide Shaun, Patel, Vyomesh
• Format: Article
• Published: Elsevier 2018
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/20526/; https://doi.org/10.1016/j.procbio.2018.07.007

Microorganisms are now recognized as a keysource of medicine. In this study, we aim to identify and characterize target-specific inhibitors from actinobacteria using zebrafish embryo developmental defect as readouts. From our preliminary screen, we evaluated 176 Malaysian actinobacteria extracts and...