Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts
Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However...
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my.um.eprints.205242019-02-27T02:49:10Z http://eprints.um.edu.my/20524/ Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts Wong, Fai Chu Tan, Siok Thing Ong, Hean Chooi Chai, Tsun Thai Q Science (General) QD Chemistry QH Natural history Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However, the exact mechanism remains elusive. Objective: In this paper, we reported the identification of six differentially expressed proteins isolated from cancer cells, following exposure to the cytotoxic fern extracts. Materials and Methods: The identities of these cancer proteins were determined by matrix-assisted laser desorption ionization time-of-flight protein sequencing. Results: The cancer proteins were identified as follows: elongation factor 1-γ, glyceraldehydes-3-phosphate dehydrogenase, heat shock protein 90-β, heterogeneous nuclear ribonucleoprotein-A2/B1, truncated nucleolar phosphoprotein B23, and tubulin-β chain. To the best of our knowledge, this paper represents thefirst time these cancer proteins are being reported, following exposure to the aforementioned cytotoxic fern extracts. Conclusion: It is hoped that further efforts in this direction could lead to the identification and development of target-specific chemotherapeutic agents. Medknow Publications 2018 Article PeerReviewed Wong, Fai Chu and Tan, Siok Thing and Ong, Hean Chooi and Chai, Tsun Thai (2018) Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts. Pharmacognosy Magazine, 14 (54). pp. 227-230. ISSN 0973-1296 https://doi.org/10.4103/pm.pm_282_17 doi:10.4103/pm.pm_282_17 |
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Q Science (General) QD Chemistry QH Natural history Wong, Fai Chu Tan, Siok Thing Ong, Hean Chooi Chai, Tsun Thai Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
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Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However, the exact mechanism remains elusive. Objective: In this paper, we reported the identification of six differentially expressed proteins isolated from cancer cells, following exposure to the cytotoxic fern extracts. Materials and Methods: The identities of these cancer proteins were determined by matrix-assisted laser desorption ionization time-of-flight protein sequencing. Results: The cancer proteins were identified as follows: elongation factor 1-γ, glyceraldehydes-3-phosphate dehydrogenase, heat shock protein 90-β, heterogeneous nuclear ribonucleoprotein-A2/B1, truncated nucleolar phosphoprotein B23, and tubulin-β chain. To the best of our knowledge, this paper represents thefirst time these cancer proteins are being reported, following exposure to the aforementioned cytotoxic fern extracts. Conclusion: It is hoped that further efforts in this direction could lead to the identification and development of target-specific chemotherapeutic agents. |
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Article |
author |
Wong, Fai Chu Tan, Siok Thing Ong, Hean Chooi Chai, Tsun Thai |
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Wong, Fai Chu Tan, Siok Thing Ong, Hean Chooi Chai, Tsun Thai |
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Wong, Fai Chu |
title |
Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
title_short |
Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
title_full |
Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
title_fullStr |
Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
title_full_unstemmed |
Identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
title_sort |
identification of potential anticancer protein targets in cytotoxicity mediated by tropical medicinal fern extracts |
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Medknow Publications |
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2018 |
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http://eprints.um.edu.my/20524/ https://doi.org/10.4103/pm.pm_282_17 |
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13.160551 |