Asymmetric Total Synthesis and Biological Evaluation of Proapoptotic Natural Myrcene-Derived Cyclohexenyl Chalcones

• Main Authors: Tiamas, Shelly Gapil, Audet, Florian, Samra, Alma Abou, Bignon, Jérome, Litaudon, Marc, Fourneau, Christophe, Ariffin, Azhar, Awang, Khalijah, Desrat, Sandy, Roussi, Fanny
• Format: Article
• Published: Wiley 2018
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/20469/; https://doi.org/10.1002/ejoc.201800262

Based on a bioinspired asymmetric Diels–Alder cycloaddition using a chiral Evans oxazolidinone, the first total synthesis of both enantiomers of two myrcene-derived cyclohexenyl chalcones, fislatifolione and fislatifolic acid, has been carried out. This strategy was also applied to the total synthes...