Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways

• Main Authors: Zahedifard, M., Faraj, F.L., Paydar, M., Looi, C.Y., Hajrezaei, M., Hasanpourghadi, M., Kamalidehghan, B., Majid, N.A., Ali, H.M., Abdulla, M.A.
• Format: Article
• Published: Nature Publishing Group 2015
• Subjects: Q Science (General); R Medicine
• Online Access: http://eprints.um.edu.my/19315/; http://dx.doi.org/10.1038/srep11544

The current study investigated the cytotoxic effect of 3-(5-chloro-2-hydroxybenzylideneamino)-2-(5-chloro-2-hydroxyphenyl)-2,3-dihydroquinazolin-41(H)-one (A) and 3-(5-nitro-2-hydroxybenzylideneamino)-2-(5-nitro-2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (B) on MCF-7, MDA-MB-231, MCF-10A and W...