Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis
Aim: To investigate fiber and prebiotic supplementation of enteral nutrition (EN) for diarrhea, fecal microbiota and short-chain fatty acids (SCFAs). Methods: MEDLINE, EMBASE, Cochrane Library, CINAHL, Academic Search Premier, and Web of Science databases were searched for human experimental and obs...
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my.um.eprints.192872019-12-16T09:21:13Z http://eprints.um.edu.my/19287/ Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis Zaman, Mazuin Kamarul Chin, Kin Fah Rai, Vineya Majid, Hazreen Abdul R Medicine Aim: To investigate fiber and prebiotic supplementation of enteral nutrition (EN) for diarrhea, fecal microbiota and short-chain fatty acids (SCFAs). Methods: MEDLINE, EMBASE, Cochrane Library, CINAHL, Academic Search Premier, and Web of Science databases were searched for human experimental and observational cohort studies conducted between January 1990 and June 2014. The keywords used for the literature search were fiber, prebiotics and enteral nutrition. English language studies with adult patient populations on exclusive EN were selected. Abstracts and/or full texts of selected studies were reviewed and agreed upon by two independent researchers for inclusion in the meta-analysis. Tools used for the quality assessment were Jadad Scale and the Scottish Intercollegiate Guidelines Network Critical Appraisal of the Medical Literature. Results: A total of 456 possible articles were retrieved, and 430 were excluded due to lack of appropriate data. Of the 26 remaining studies, only eight investigated the effects of prebiotics. Results of the meta-analysis indicated that overall, fiber reduces diarrhea in patients receiving EN (OR = 0.47; 95%CI: 0.29-0.77; P = 0.02). Subgroup analysis revealed a positive effect of fiber supplementation in EN towards diarrhea in stable patients (OR = 0.31; 95%CI: 0.19-0.51; P < 0.01), but not in critically ill patients (OR = 0.89; 95%CI: 0.41-1.92; P = 0.77). Prebiotic supplementation in EN does not improve the incidence of diarrhea despite its manipulative effect on bifidobacteria concentrations and SCFA in healthy humans. In addition, the effect of fiber and/or prebiotic supplementation towards fecal microbiota and SCFA remain disputable. Conclusion: Fiber helps minimize diarrhea in patients receiving EN, particularly in non-critically ill patients. However, the effect of prebiotics in moderating diarrhea is inconclusive. Maney Publishing 2015 Article PeerReviewed Zaman, Mazuin Kamarul and Chin, Kin Fah and Rai, Vineya and Majid, Hazreen Abdul (2015) Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis. World Journal of Gastroenterology, 21 (17). p. 5372. ISSN 1007-9327 http://dx.doi.org/10.3748/wjg.v21.i17.5372 doi:10.3748/wjg.v21.i17.5372 |
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R Medicine Zaman, Mazuin Kamarul Chin, Kin Fah Rai, Vineya Majid, Hazreen Abdul Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis |
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Aim: To investigate fiber and prebiotic supplementation of enteral nutrition (EN) for diarrhea, fecal microbiota and short-chain fatty acids (SCFAs). Methods: MEDLINE, EMBASE, Cochrane Library, CINAHL, Academic Search Premier, and Web of Science databases were searched for human experimental and observational cohort studies conducted between January 1990 and June 2014. The keywords used for the literature search were fiber, prebiotics and enteral nutrition. English language studies with adult patient populations on exclusive EN were selected. Abstracts and/or full texts of selected studies were reviewed and agreed upon by two independent researchers for inclusion in the meta-analysis. Tools used for the quality assessment were Jadad Scale and the Scottish Intercollegiate Guidelines Network Critical Appraisal of the Medical Literature. Results: A total of 456 possible articles were retrieved, and 430 were excluded due to lack of appropriate data. Of the 26 remaining studies, only eight investigated the effects of prebiotics. Results of the meta-analysis indicated that overall, fiber reduces diarrhea in patients receiving EN (OR = 0.47; 95%CI: 0.29-0.77; P = 0.02). Subgroup analysis revealed a positive effect of fiber supplementation in EN towards diarrhea in stable patients (OR = 0.31; 95%CI: 0.19-0.51; P < 0.01), but not in critically ill patients (OR = 0.89; 95%CI: 0.41-1.92; P = 0.77). Prebiotic supplementation in EN does not improve the incidence of diarrhea despite its manipulative effect on bifidobacteria concentrations and SCFA in healthy humans. In addition, the effect of fiber and/or prebiotic supplementation towards fecal microbiota and SCFA remain disputable. Conclusion: Fiber helps minimize diarrhea in patients receiving EN, particularly in non-critically ill patients. However, the effect of prebiotics in moderating diarrhea is inconclusive. |
format |
Article |
author |
Zaman, Mazuin Kamarul Chin, Kin Fah Rai, Vineya Majid, Hazreen Abdul |
author_facet |
Zaman, Mazuin Kamarul Chin, Kin Fah Rai, Vineya Majid, Hazreen Abdul |
author_sort |
Zaman, Mazuin Kamarul |
title |
Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis |
title_short |
Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis |
title_full |
Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis |
title_fullStr |
Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis |
title_full_unstemmed |
Fiber and prebiotic supplementation in enteral nutrition: A systematic review and meta-analysis |
title_sort |
fiber and prebiotic supplementation in enteral nutrition: a systematic review and meta-analysis |
publisher |
Maney Publishing |
publishDate |
2015 |
url |
http://eprints.um.edu.my/19287/ http://dx.doi.org/10.3748/wjg.v21.i17.5372 |
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13.188404 |