Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

• Main Authors: Chung, F.F.L., Tan, P.F.T.M., Raja, V.J., Tan, B.S., Lim, K.H., Kam, T.S., Hii, L.W., Tan, S.H., See, S.J., Tan, Y.F., Wong, L.Z., Yam, W.K., Mai, C.W., Bradshaw, T.D., Leong, C.O.
• Format: Article
• Published: Nature Publishing Group 2017
• Subjects: QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/19199/; http://dx.doi.org/10.1038/srep42504

Precursor mRNA (pre-mRNA) splicing is catalyzed by a large ribonucleoprotein complex known as the spliceosome. Numerous studies have indicated that aberrant splicing patterns or mutations in spliceosome components, including the splicing factor 3b subunit 1 (SF3B1), are associated with hallmark canc...