DNA-binding studies of valrubicin as a chemotherapy drug using spectroscopy and electrochemical techniques

• Main Authors: Hajian, R., Hossaini, P., Mehrayin, Z., Woi, P.M., Shams, N.
• Format: Article
• Published: Elsevier 2017
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/19177/; http://dx.doi.org/10.1016/j.jpha.2017.01.003

In this study, the molecular interactions between valrubicin, an anticancer drug, and fish sperm DNA have been studied in phosphate buffer solution (pH 7.4) using UV–Vis spectrophotometry and cyclic voltammetry techniques. Valrubicin intercalated into double stranded DNA under a weak displacement re...