2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation

• Main Authors: Lai, J.K.F., Sam, I.C., Verlhac, P., Baguet, J., Eskelinen, E.L., Faure, M., Chan, Y.F.
• Format: Article
• Published: MDPI 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/19131/; http://dx.doi.org/10.3390/v9070169

Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo. In this study, we report that EV-A71 triggers autolysosome formation during infection in human rhabdomyosarcoma (RD) cells to facilitate i...