NMDA receptor antagonism with novel indolyl, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy

• Main Authors: Rothan, H.A., Amini, E., Faraj, F.L., Golpich, M., Teoh, T.C., Gholami, K., Yusof, R.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2017
• Subjects: Q Science (General); R Medicine
• Online Access: http://eprints.um.edu.my/19038/1/NMDA_receptor_antagonism_with_novel_indolyl.pdf; http://eprints.um.edu.my/19038/; http://dx.doi.org/10.1038/srep45540

N-methyl-D-aspartate receptors (NMDAR) play a central role in epileptogensis and NMDAR antagonists have been shown to have antiepileptic effects in animals and humans. Despite significant progress in the development of antiepileptic therapies over the previous 3 decades, a need still exists for nove...