Persistent infection due to a small-colony variant of Burkholderia pseudomallei leads to PD-1 upregulation on circulating immune cells and mononuclear infiltration in viscera of experimental BALB/c mice

• Main Authors: See, J.X., Chandramathi, S., Abdulla, M.A., Vadivelu, J., Shankar, E.M.
• Format: Article
• Language: English
• Published: Public Library of Science 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/19034/1/Persistent_infection_due_to_a_small-colony_variant_of_Burkholderia_pseudomallei_leads_to_PD-1_upregulation_on_circulating_immune_cells_and_mononuclear_infiltration.pdf; http://eprints.um.edu.my/19034/; http://dx.doi.org/10.1371/journal.pntd.0005702

Background: Melioidosis is a neglected tropical disease endemic across South East Asia and Northern Australia. The etiological agent, Burkholderia pseudomallei (B.pseudomallei), is a Gram-negative, rod-shaped, motile bacterium residing in the soil and muddy water across endemic regions of the tropic...