Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming

• Main Authors: Chandrabose, S.T., Sriram, S., Subramanian, S., Cheng, S.S., Ong, W.K., Rozen, S., Abu Kasim, N.H., Sugii, S.
• Format: Article
• Language: English
• Published: BioMed Central 2018
• Subjects: RK Dentistry
• Online Access: http://eprints.um.edu.my/18900/1/s13287-018-0796-2.pdf; http://eprints.um.edu.my/18900/; https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-018-0796-2

Background: While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sources and protocols for efficient reprogramming. Methods: Here, we show a robust...