Relationship Between ABCB1 Polymorphisms and Cold Pain Sensitivity Among Healthy Opioid-naive Malay Males

• Main Authors: Zahari, Z., Lee, C.S., Ibrahim, M.A., Musa, N., Mohd Yasin, M.A., Lee, Y.Y., Tan, S.C., Mohamad, N., Ismail, R.
• Format: Article
• Published: Blackwell Publishing 2017
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/18862/; https://doi.org/10.1111/papr.12546

Background: Endogenous and exogenous opioids are substrates of the permeability glycoprotein (P-gp) efflux transporter, which is encoded by the ABCB1 (MDR1) gene. Genetic polymorphisms of ABCB1 may contribute to interindividual differences in pain modulation and analgesic responses. We investigated...