Rational Design and Synthesis of New, High Efficiency, Multipotent Schiff Base-1,2,4-triazole Antioxidants Bearing Butylated Hydroxytoluene Moieties

• Main Authors: Yehye, Wageeh Abdulhadi, Abd Rahman, Noorsaadah, Saad, O., Ariffin, Azhar, Hamid, Sharifah Bee Abd, Alhadi, A.A., Kadir, F.A., Yaeghoobi, M., Matlob, A.A.
• Format: Article
• Published: MDPI 2016
• Subjects: Q Science (General); QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/18789/; http://dx.doi.org/10.3390/molecules21070847

A new series of multipotent antioxidants (MPAOs), namely Schiff base-1,2,4-triazoles attached to the oxygen-derived free radical scavenging moiety butylated hydroxytoluene (BHT) were designed and subsequently synthesized. The structure-activity relationship (SAR) of the designed antioxidants was est...